Use of an ophthalmic formulation of Megestrol acetate for the treatment of eosinophilic keratitis in cats

Fonte: Jean Stiles, Martin Coster

(a) Eosinophilic keratitis is present throughout the right cornea. (b) The left cornea is similarly affected although to a lesser degree.(c, d) Three weeks after treating with topical 0.5% megestrol acetate q 8 h in both eyes, the lesions have resolved. Mild residual corneal vascularization is visible in the left eye (d)
   (a) Eosinophilic keratitis is present throughout the right cornea. (b) The left cornea is similarly affected although to a lesser degree.(c, d) Three weeks after treating with topical 0.5% megestrol acetate q 8 h in both eyes, the lesions have resolved. Mild residual corneal vascularization is visible in the left eye (d)

Objective:To evaluate a compounded ophthalmic formulation of 0.5% megestrol acetate to treat eosinophilic keratitis in cats.Study design: Prospective study.Animals studiedSeventeen client owned cats with eosinophilic keratitis in one or both eyes. Methods: Eosinophilic keratitis was confirmed by cytology. At each visit, fluorescein staining and photography were performed. Cats were initially treated q 8–12 h with0.5% acetate in an aqueous base. Serum glucose was measured at the first or second reexamination.ResultsFifteen of 17 (88%) cats had a positive response to treatment, with 6 of 17(35%) having complete resolution at the first reexamination (2–4 weeks). Two of 17(12%) cats did not respond to treatment. Most cats required a treatment frequency of once daily to once weekly to maintain remission of disease. No ocular irritation or systemic side effects were noted in any cat.Conclusions and clinical relevanceThe use of an ophthalmic formulation of 0.5% megestrol acetate is a viable option for treating feline eosinophilic keratitis.

 

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